Distribution of the epidermal growth factor receptor during the initial hair cycle of C57-BL/6J-A?-? and downy mice

dc.contributor.advisorHardy-Fallding, M.H.
dc.contributor.advisorFisher, K.R.S.
dc.contributor.authorRobertson, Jennifer Vivian
dc.degree.departmentDepartment of Biomedical Sciencesen_US
dc.degree.grantorUniversity of Guelphen_US
dc.degree.nameMaster of Scienceen_US
dc.description.abstractExpression of the epidermal growth factor (EGF-R) in the initial hair growth cycle in a standard strain of laboratory mice, C57-BL/6J-A$\sp{w-j}$, and a novel mutant termed "downy" was examined through indirect immunofluorescence microscopy. Results show that the EGF-R is expressed similarly in the two types of mouse. The interfollicular epidermis stains intensely and the dermis remains negative throughout the initial cycle of follicle development. The follicle epithelium stains faintly in early anagen stages (1-3c) and then intensely in later anagen stages and for the rest of the initial cycle. The dermal papilla shows no staining in anagen; yet, surprisingly, demonstrates a faint stain during catagen and telogen. These results support findings of other studies that indicate that the EGF-R is not needed to initiate or maintain anagen hair follicles (Green and Couchman, 1984a), yet it is needed for entry into the catagen phase (Murillas et al, 1995). Possible reasons for the faint expression of EGF-R in the dermal papilla in catagen and telogen are discussed.en_US
dc.publisherUniversity of Guelphen_US
dc.rights.licenseAll items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectepidermal growth factoren_US
dc.subjectinitial hair growth cycleen_US
dc.subjectlaboratory miceen_US
dc.subjectfollicle epithelium stainsen_US
dc.titleDistribution of the epidermal growth factor receptor during the initial hair cycle of C57-BL/6J-A?-? and downy miceen_US
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