Genetic polymorphisms in skeletal muscle metaboreceptors are associated with blood pressure responses to exercise

dc.contributor.advisorMillar, Philip
dc.contributor.authorNotay, Karambir of Human Health and Nutritional Sciencesen_US of Guelphen_US of Scienceen_US Health and Nutritional Sciencesen_US
dc.description.abstractThis thesis examined whether single-nucleotide polymorphisms (SNPs) in genes encoding for metaboreceptors present in skeletal muscle afferents can influence responses to exercise. Two hundred healthy young participants underwent continuous measurements of blood pressure (BP) at baseline and during 2-min of static handgrip and 2-min of serial subtraction in a randomized order. Participants were genotyped for SNPs in TRPV1 (rs222747; G/C), ASIC3 (rs2288645; G/A), BDKRB2 (rs1799722; C/T), PTGER2 (rs17197; A/G), and P2RX4 (rs25644; A/G). Exercise systolic BP was lower in GG versus GC/CC minor allele carriers for TRPV1 rs222747, while exercise diastolic BP were lower in CC versus CT/TT minor allele carriers for BDKRB2 rs1799722. Individuals carrying both minor alleles for TRPV1 rs222747 and BDKRB2 rs1799722 had greater systolic and diastolic BP responses than those carrying no minor alleles. These findings demonstrate that variants in TRPV1 and BDKRB2 receptors can contribute to BP differences during static exercise in an additive manner.en_US
dc.description.sponsorshipNatural Science and Engineering Research Council of Canada - Discovery Grant (P.J.M. #06019)
dc.description.sponsorshipCanada Foundation for Innovation (P.J.M. #34379)
dc.description.sponsorshipUniversity of Guelph-Humber Research Fund Grant (P.J.M)
dc.description.sponsorshipOntario Ministry of Research, Innovation, and Science (P.J.M. #34379)
dc.description.sponsorshipNatural Sciences and Engineering Research Council of Canada - Alexander Graham Bell Canada Graduate Scholarship
dc.publisherUniversity of Guelphen_US
dc.rights.licenseAll items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectSingle Nucleotide Polymorphismsen_US
dc.subjectBlood Pressureen_US
dc.subjectMuscle metaboreflexen_US
dc.titleGenetic polymorphisms in skeletal muscle metaboreceptors are associated with blood pressure responses to exerciseen_US


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