Myostatin Expression in the Heart is Temporally and Regionally Distinct

dc.contributor.advisorSimpson, Jeremy
dc.contributor.authorSavinova, Iryna
dc.date.accessioned2021-05-10T14:53:30Z
dc.date.available2021-05-10T14:53:30Z
dc.date.copyright2021-04
dc.date.created2021-04-28
dc.degree.departmentDepartment of Human Health and Nutritional Sciencesen_US
dc.degree.grantorUniversity of Guelphen_US
dc.degree.nameMaster of Scienceen_US
dc.degree.programmeHuman Health and Nutritional Sciencesen_US
dc.description.abstractRecently, myostatin, a protein produced by the skeletal muscle to regulate muscle growth, has been identified in other tissues including the heart. However, its expression across the healthy and diseased heart, which would provide insight into its physiological significance, is currently unknown. Thus, our aim was to determine whether myostatin expression across the heart is uniform or region-specific. Using qPCR, we measured myostatin mRNA levels in both ventricles and the septum of healthy and failing mouse hearts at various time points post-myocardial infarction (MI). Unexpectedly, the right ventricle was the main source of myostatin in healthy mice. Post-MI, myostatin expression was unique, both in time course and magnitude, across each cardiac region. Given that location provides insight into physiological function, understanding the specific region of myostatin expression within the heart is the first necessary step to determine the stressors that drive its response and corresponding autocrine, paracrine, and/or endocrine functions.en_US
dc.identifier.urihttps://hdl.handle.net/10214/25693
dc.language.isoenen_US
dc.publisherUniversity of Guelphen_US
dc.rights.licenseAll items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectright ventricleen_US
dc.subjectgene expressionen_US
dc.subjectqPCRen_US
dc.subjectmyocardial infarctionen_US
dc.subjectheart failureen_US
dc.subjectTGFBen_US
dc.subjectmRNAen_US
dc.subjectactivinen_US
dc.subjectfollistatinen_US
dc.subjectfollistatin-like-3en_US
dc.titleMyostatin Expression in the Heart is Temporally and Regionally Distincten_US
dc.typeThesisen_US

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