Liver oxygenation in chronic ethanol-treated rats: Analysis by functional magnetic resonance imaging

dc.contributor.advisorBrauer, M.
dc.contributor.authorYau, Melissa of Chemistry and Biochemistryen_US of Guelphen_US of Scienceen_US
dc.description.abstractThis thesis is an investigation of functional Magnetic Resonance Imaging (MRI) to examine oxygenation changes in pair-fed and chronic ethanol-treated rat livers during hypoxic, hyperoxic, hypercapnic or carbogen inhalation challenge, or after acute ethanol administration. The change in signal intensity in Magnetic Resonance images was positively correlated (r2 = 0.92, p < 0.05) with oxygen saturation measurements in both pair-fed and chronic ethanol-treated rats. The hepatic artery and the portal vein extraction coefficients and the lactate-to-pyruvate ratios were all in agreement with functional MRI results during each challenge. The magnitudes of signal intensity change in T 2 and T2*-weighted Magnetic Resonance images were smaller in chronic ethanol-treated rats in comparison to their pair-fed controls for all the inhalation challenges, consistent with chronic ethanol-induced hepatic microvascular dysfunction. In conclusion, functional MRI was shown to be a sensitive, reliable indicator of hepatic oxygenation changes, and showed subtle, early effects of chronic ethanol consumption on the liver.en_US
dc.publisherUniversity of Guelphen_US
dc.rights.licenseAll items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectfunctional Magnetic Resonance Imagingen_US
dc.subjectoxygenation changesen_US
dc.subjectchronic ethanol consumptionen_US
dc.subjectrat liversen_US
dc.subjectliver oxygenationen_US
dc.titleLiver oxygenation in chronic ethanol-treated rats: Analysis by functional magnetic resonance imagingen_US


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