Synthesis of selected fragments of the Lewis B Lewis A Tumor-Associated Carbohydrate Antigen

dc.contributor.advisorAuzanneau, France-Isabelle
dc.contributor.authorDavidson, Jeffrey
dc.date.accessioned2021-10-01T15:23:21Z
dc.date.available2021-10-01T15:23:21Z
dc.date.copyright2021-09-29
dc.date.created2021-09-14
dc.degree.departmentDepartment of Chemistryen_US
dc.degree.grantorUniversity of Guelphen_US
dc.degree.nameDoctor of Philosophyen_US
dc.degree.programmeChemistryen_US
dc.description.abstractCarbohydrates are the most abundant class of natural products found in living organisms. They are present on the surface of cells and play a vital role in cell recognition. It has been observed that tumor cells overexpress some oligosaccharides on their surface. These oligosaccharides have been named Tumor-Associated Carbohydrate Antigens (TACA). One TACA of interest to our research group is the LebLea heptaasaccharide, which is displayed on the surface of liver, pancreas and endometrium carcinomas. Carbohydrates are immunogenic, therefore, it is possible to design a carbohydrate-based vaccine against these tumor cells. However, an immune response against LebLea would likely result in an auto-immune response as Leb is found on healthy cells. If a fragment of LebLea is used instead, it is quite possible that an immune response is raised against LebLea while being harmless to normal healthy cells. This thesis describes the synthesis of tri- tetra- and pentasaccharide fragments of LebLea. The synthesized fragments can then be subjected to immunochemical studies to test for cross-reactivity. Successful results may lead to a potential carbohydrate based anticancer vaccine for the proposed TACA LebLea.en_US
dc.identifier.urihttps://hdl.handle.net/10214/26494
dc.language.isoenen_US
dc.publisherUniversity of Guelphen_US
dc.rights.licenseAll items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectCanceren_US
dc.subjectTACAen_US
dc.subjectCarbohydrateen_US
dc.titleSynthesis of selected fragments of the Lewis B Lewis A Tumor-Associated Carbohydrate Antigenen_US
dc.typeThesisen_US

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