Only a small fraction of tumour-infiltrating immune cells possess special anti-tumour proteins
Date
2013-03-04
Authors
Neta, M.
Wood, D.
Jacobs, R.M.
Institute for Community Engaged Scholarship
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Abstract
CCH tumour regression was associated with widespread invasion by TILs, despite the fact that only a small fraction of TILs possessed the anti-cancer proteins perforin and granzyme. Since many granzyme-positive TILs did not contain perforin, some TIL may have perforin-independent ways of killing cancerous cells.
Description
This summary is a project of the Institute for Community Engaged Scholarship (ICES) at the University of Guelph, with project partners: the Catalyst Centre, SPARK Program at the University of Guelph, and Knowledge Mobilization Unit at York University. This project is part of the Pan-Canadian Research Impact Network. http://csahs.uoguelph.ca/pps/Clear_Research
Keywords
Cancer, tumour regression, lymphocytes, histiocytoma, perforin, granzyme