Assessing the suitability of Cervidil(TM) to facilitate artificial insemination and embryo transfer in ewes

dc.contributor.advisorBartlewski, Pawel
dc.contributor.authorCandappa, Ivanka
dc.date.accessioned2020-08-24T15:48:41Z
dc.date.available2020-08-24T15:48:41Z
dc.date.copyright2010
dc.degree.departmentDepartment of Biomedical Sciencesen_US
dc.degree.grantorUniversity of Guelphen_US
dc.degree.nameMaster of Scienceen_US
dc.description.abstractThe present study set out to assess the efficacy of Cervidil® , a patented dinoprostone-containing vaginal insert with a slow-release mechanism, to safely induce sufficient cervical dilation for the purpose of transcervical artificial insemination (TCAI) or embryo transfer (TCET) in ewes. TCAI during seasonal anestrus (n=40) and the breeding season (n=40), and TCET during seasonal anestrus (n=23) were performed on multiparous Rideau Arcott x Dorset ewes with or without the pre-treatment with Cervidil ® (for a duration of 12 or 24 hours prior to TCAI/ET). Cervidil® priming significantly reduced the average time required for TCAI during the breeding season in comparison to controls (54 sec vs. 98 sec), especially after the 24-hour exposure (38 sec vs. 108 sec). Cervical penetration rate was significantly improved after Cervidil® pre-treatment during TCET, with 55% of treated versus 9% of control animals successfully penetrated. These results indicate a significant benefit of using Cervidil ® for inducing cervical dilation in non-pregnant ewes.en_US
dc.identifier.urihttps://hdl.handle.net/10214/20213
dc.language.isoen
dc.publisherUniversity of Guelphen_US
dc.rights.licenseAll items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectCervidilen_US
dc.subjectSuitabilityen_US
dc.subjectArtificial inseminationen_US
dc.subjectEmbryo transferen_US
dc.subjectEwesen_US
dc.titleAssessing the suitability of Cervidil(TM) to facilitate artificial insemination and embryo transfer in ewesen_US
dc.typeThesisen_US

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