Cytokines, dendritic cells and toll-like receptors in the success and failure of porcine pregnancy

dc.contributor.advisorHahnel, Ann
dc.contributor.advisorTayade, Chandrakant
dc.contributor.advisorCroy, B. Anne
dc.contributor.authorLinton, Nicola Frances of Biomedical Sciencesen_US of Guelphen_US of Scienceen_US
dc.description.abstractCommercial swine exhibit two spontaneous waves of conceptus loss during gestation. Arresting conceptus attachment sites are associated with decreased angiogenesis and elevated pro-inflammatory cytokine production by lymphocytes. No studies have addressed type 1 and 2 cytokine ratios in pregnant pigs or the presence of DC-SIGN+ DCs, their activation status and angiogenic potential. I hypothesized that type 1 and 2 cytokine ratios are altered at the porcine maternal-fetal interface by pregnancy failure. Further, I postulated that DCs contribute to angiogenesis in healthy pregnancy and conceptus loss is associated with engagement of TLRs. Cytokine ratios and TLR expression were quantified at the maternal-fetal interface at early and mid gestation. DC-SIGN+ DC-like cells were found and their expression of TLRs and angiogenesis-related molecules was addressed. These studies implicate endometrial DC-like cells in the regulation of angiogenesis in pig pregnancy and provide a model for roles of DCs in human pregnancy loss.en_US
dc.publisherUniversity of Guelphen_US
dc.rights.licenseAll items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjecttype 1 cytokineen_US
dc.subjecttype 2 cytokineen_US
dc.subjectporcine maternal-fetal interfaceen_US
dc.subjectpregnancy failureen_US
dc.subjectdendritic cellsen_US
dc.subjecttoll-like receptorsen_US
dc.titleCytokines, dendritic cells and toll-like receptors in the success and failure of porcine pregnancyen_US


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