A study of the genesis of rhabdomyosarcomas induced with nickel sulfide in the rat

dc.contributor.authorHerchen, Heinrich Herchen
dc.date.accessioned2013-01-29T20:51:24Z
dc.date.available2013-01-29T20:51:24Z
dc.date.copyright1963
dc.date.issued2013-01-29
dc.degree.grantorUniversity of Guelphen_US
dc.descriptionA thesis submitted in partial fulfillment of the requirements for the Degree of Master of Veterinary Science to the School of Graduate Studies, University of Toronto, 1963en_US
dc.description.abstractInvestigations carried out by Hueper (1955, 1957, 1958) and Hueper and Payne (1959) have contributed to our present knowledge of the cancerogenecity of metals and their role as occupational hazards, particularly in respect to lung cancer. Hueper considers arsenic, asbestos, chromium and nickel to be established metallurgical carcinogens. Besides epidemiological investigations, Hueper and co-workers administered various forma of chromium and nickel parenterally and powdered metallic nickel by inhalation in their studies of metal cancerigenesis. Cobalt was reported by Heath (1954, 1956) to be a potent carcinogen in rats with rhabdomyosarcomas amongst the neoplasms observed following intramuscular injection. Gillman and Ruckebauer (1962) confirmed these findings and stressed the high proportion of a "type of sarcoma that is clearly of muscle origin". They found that mice did not respond at all to this cancerigenic stimulus, a fact also noted by Heath (1959). Gilman (1962) showed in later work that nickel sulfide and oxide and the corresponding cobalt compounds were cancerigenic in rats on intramuscular injection. Again a very high percentage of the cobalt and nickel-induced tumours were rhabdomyosarcomas. However, the soluble nickel...en_US
dc.identifier.urihttp://hdl.handle.net/10214/5413
dc.language.isoenen_US
dc.publisherUniversity of Guelphen_US
dc.rightsThis work may be protected by copyright laws and is provided for educational and research purposes only. If you believe you are the rights holder and object to the University of Guelph's use of this document, please contact libair@uoguelph.ca.*
dc.rights.licenseAll items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectnickel sulfideen_US
dc.subjectraten_US
dc.subjecttumoren_US
dc.subjectrhabdomyosarcomaen_US
dc.titleA study of the genesis of rhabdomyosarcomas induced with nickel sulfide in the raten_US

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