Structure and function of healthy and osteoarthritic posteromedial knee joint capsule

dc.contributor.advisorGordon, Karen
dc.contributor.advisorHurtig, Mark
dc.contributor.authorSteeds, Justin
dc.date.accessioned2021-05-28T14:47:53Z
dc.date.available2021-05-28T14:47:53Z
dc.date.copyright2010
dc.degree.departmentSchool of Engineeringen_US
dc.degree.grantorUniversity of Guelphen_US
dc.degree.nameMaster of Applied Scienceen_US
dc.description.abstractTo characterize the structure and function of posteromedial knee joint capsule (PMC), uniaxial biomechanical testing, polarized light microscopy (PLM) and environmental scanning electron microscopy (ESEM) were performed on contralateral and osteoarthritic (OA) ovine joint capsule. Biaxial testing was performed on healthy tissue alone. Uniaxial test results showed an increase in stiffness of OA capsule compared to contralateral and a decrease in stiffness as the joint flexed. Collagen fibre orientation of ovine PMC using PLM of contralateral tissue had a symmetrical bimodal distribution oblique to the medial-lateral anatomical axis, while osteoarthritic PMC had a unimodal distribution coincident with the medial-lateral axis. ESEM revealed that OA PMC had statistically significant smaller collagen fibre diameters than contralateral PMC. Biaxial test results showed a trend towards increased stiffness in the proximal-distal axis compared to the medial-lateral axis. Principle stiff-strain orientation yielded a trend of a symmetrical bimodal distribution oblique to the medial-lateral anatomical axis.en_US
dc.identifier.urihttps://hdl.handle.net/10214/25865
dc.language.isoen
dc.publisherUniversity of Guelphen_US
dc.rights.licenseAll items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectstructureen_US
dc.subjectfunctionen_US
dc.subjectposteromedial knee joint capsuleen_US
dc.subjectuniaxial biomechanical testingen_US
dc.subjectpolarized light microscopyen_US
dc.subjectenvironmental scanning electron microscopyen_US
dc.subjectcontralateralen_US
dc.subjectosteoarthriticen_US
dc.subjectovine joint capsuleen_US
dc.titleStructure and function of healthy and osteoarthritic posteromedial knee joint capsuleen_US
dc.typeThesisen_US

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