Efficacy of gastric-acid lowering therapy in the dog
This thesis is an investigation of the normal canine gastric acid profile and the degree of gastric acid suppression achieved using antisecretory drugs. Continuous 24-hour intragastric pH measurements were obtained in fasted and fed dogs. Thereafter, a randomized, multiple cross-over study compared saline IV q12h, ranitidine 2mg/kg IV q12h, famotidine 0.5mg/kg IV q12h, pantoprazole 1mg/kg IV q24h, and omeprazole ~1mg/kg PO q24h, for 7 days. Recordings were obtained on Day 0, 2, and 6. Next, famotidine 0.5mg/kg IV q8h and omeprazole suspension (~1mg/kg) PO q12h were evaluated in 6 dogs. The median pH and the percent time pH >= 3 and pH >= 4 were compared. Fasting produced greater acid suppression than feeding. Famotidine, pantoprazole and omeprazole showed significant acid suppression based on median 24-h pH and percent time pH >= 3 and >= 4. Omeprazole suspension q12h was the most effective at suppressing gastric acid secretion.