Genome-wide Analysis of Copy Number Aberrations in Canine Osteosarcoma

dc.contributor.advisorWood, Geoffrey
dc.contributor.authorLiu, Jonathan
dc.date.accessioned2011-09-16T18:29:03Z
dc.date.available2011-09-16T18:29:03Z
dc.date.copyright2011-09
dc.date.created2011-09-09
dc.date.issued2011-09-16
dc.degree.departmentDepartment of Pathobiologyen_US
dc.degree.grantorUniversity of Guelphen_US
dc.degree.nameMaster of Scienceen_US
dc.degree.programmePathobiologyen_US
dc.description.abstractCanine osteosarcoma (OSA) is the most common bone tumour in dogs and is characterized by massive genomic instability throughout the cancer genome. Using matched primary tumour and metastasis samples from 8 OSA cases, we identified 2 focally deleted (<0.2 Mb) novel candidate genes, cyclin-dependent kinase inhibitor 2B (CDKN2B) and the membrane associated guanylate kinase, WW and PDZ domain containing 2 (MAGI2), which have not been previously identified in canine OSA and may have roles in driving OSA tumour progression. We also identified highly similar genomic profiles between matched samples, which yielded a small list of candidate regions that may harbour genes that drive metastasis formation. This study identified potential therapeutic targets, prognostic markers and early detectors of metastasis, in addition to providing insight into the OSA tumour progression.en_US
dc.identifier.urihttp://hdl.handle.net/10214/3023
dc.language.isoenen_US
dc.publisherUniversity of Guelphen_US
dc.rights.licenseAll items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectCanine Osteosarcomaen_US
dc.titleGenome-wide Analysis of Copy Number Aberrations in Canine Osteosarcomaen_US
dc.typeThesisen_US

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