Spatial and temporal epidemiology of feline immunodeficiency virus and feline leukemia virus infections in the United States and Canada

dc.contributor.advisorBerke, Olaf
dc.contributor.authorChhetri, Bimal of Population Medicineen_US of Guelphen_US of Philosophyen_US Medicineen_US
dc.description.abstractThis thesis investigates the geographical and temporal variations in feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV) infections, and the importance of known risk factors for these infections relative to each other in the United States and Canada. In addition, the effect of the modifiable areal unit problem (MAUP) on commonly used spatial analysis methods was assessed. Choropleth mapping and spatial scan testing revealed that compared to FIV, FeLV infection was predominant in western regions, and FIV infection was predominant in eastern regions of the US. A multilevel case-case study design for comparison of FIV and FeLV infections indicated that cats that were adult, male, healthy, or outdoor cats were more likely to be seropositive for FIV compared to FeLV when compared to juvenile, female, sick or cats kept exclusively indoors. Neuter status and testing at clinic or shelter did not differ significantly between the two infections. Time series analysis did not reveal an increasing or decreasing trend in FIV or FeLV seropositivity among cats tested at the Animal Health Laboratory (AHL) from 1999-2012. Further, the FIV vaccine introduction did not have a significant effect on changing seroprevalence for FIV. It was evident from this study that commonly used spatial epidemiological methods (Moran's I, the spatial scan test and spatial Poisson regression modeling) are sensitive to the choice of the spatial aggregation scale (state, county, postal code levels) for analysis, (i.e., are affected by the MAUP). The MAUP effect was expressed as differences in strength and significance of clustering, differences in size and number of clusters detected, and differences in significance and magnitude of associations between FIV or FeLV infections and predictor variables as the level of aggregation changed.en_US
dc.description.sponsorshipOntario Veterinary College Fellowship
dc.publisherUniversity of Guelphen_US
dc.rights.licenseAll items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectFeline leukemiaen_US
dc.subjectFeline retrovirusen_US
dc.subjectSpatial epidemiologyen_US
dc.subjectFeline immunodeficiency virusen_US
dc.titleSpatial and temporal epidemiology of feline immunodeficiency virus and feline leukemia virus infections in the United States and Canadaen_US


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