Investigating skeletal muscle passive mechanical properties: the effects of fibre type, muscle, age, and species

dc.contributor.advisorBrown, Stephen
dc.contributor.authorNoonan, Alex
dc.date.accessioned2018-09-05T16:01:17Z
dc.date.available2018-09-05T16:01:17Z
dc.date.copyright2018
dc.date.created2018-08-22
dc.date.issued2018-09-05
dc.degree.departmentDepartment of Human Health and Nutritional Sciencesen_US
dc.degree.grantorUniversity of Guelphen_US
dc.degree.nameMaster of Scienceen_US
dc.degree.programmeHuman Health and Nutritional Sciencesen_US
dc.description.abstractCurrently, there is a gap in the literature regarding information on the passive mechanical properties of the various fibre and muscle types, as well as how passive muscle mechanical properties change with age and differ across species. As such, passive muscle stiffness (elastic modulus) of single muscle fibres were investigated in the current thesis. The purpose of this thesis was to: investigate what effect fibre type (type 1 versus type 2) had on passive elastic moduli; to compare passive elastic moduli amongst the rat hindlimb muscles (Tibialis Anterior (TA), Soleus (SOL), and Gastrocnemius (GAST)); to compare passive elastic moduli in young and old humans. Single muscle fibres were placed in a relaxing solution and repeatedly stretched to calculate the elastic modulus. Fibre types were determined via gel electrophoresis (SDS-PAGE). Type 1 fibres were stiffer then type 2 fibres; however when accounting for fibre diameter, this difference no longer existed. There was no difference in stiffness amongst the hindlimb muscles of the rat. “Young” single fibres were stiffer then “old” single fibres. Single fibres from humans were stiffer than single fibres from the rat hindlimb. Together these data improve the current understanding of passive muscle properties of the various fibre and muscle types, as well as how passive muscle properties change with age and differ across species.en_US
dc.identifier.urihttp://hdl.handle.net/10214/14204
dc.language.isoenen_US
dc.publisherUniversity of Guelphen_US
dc.rights.licenseAll items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectmuscle mechanicsen_US
dc.subjectmuscle physiologyen_US
dc.subjectpassive stiffnessen_US
dc.subjectageingen_US
dc.titleInvestigating skeletal muscle passive mechanical properties: the effects of fibre type, muscle, age, and speciesen_US
dc.typeThesisen_US

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