Evaluation of a Transdermal Drug Delivery System for Veterinary Patients

dc.contributor.advisorJohnson, Ronald
dc.contributor.authorKumagai, Miyuki
dc.date.accessioned2014-08-27T18:26:50Z
dc.date.available2014-08-27T18:26:50Z
dc.date.copyright2014-08
dc.date.created2014-08-21
dc.date.issued2014-08-27
dc.degree.departmentDepartment of Biomedical Sciencesen_US
dc.degree.grantorUniversity of Guelphen_US
dc.degree.nameMaster of Scienceen_US
dc.degree.programmeBiomedical Sciencesen_US
dc.description.abstractCanine osteoarthritis (OA) is a progressive degenerative disease often leading to inflammation, pain and disuse of the affected joint. Meloxicam, commonly used to manage canine OA, is given as oral tablets or suspensions, or intravenous (IV) or subcutaneous (SC) injections. However, these routes are associated with decreased owner compliance and adverse drug reactions (ADRs) with chronic use. delivra™ uses the transdermal delivery route to transport meloxicam. Meloxicam compounded in delivra™ (TDM) was investigated to evaluate i) penetration of meloxicam into canine synovial fluid (SF) and plasma, ii) stability of TDM and iii) anti-inflammatory and analgesic properties of TDM. Results demonstrated that delivra™ was able to transport meloxicam to canine SF and plasma at comparable levels to oral Metacam® suspension and meloxicam was stable in delivra™ for up to 2 months. However, initial work with TDM did not demonstrate significant anti-inflammatory or analgesic effects in a rat model of inflammation.en_US
dc.description.sponsorshipOntario Veterinary College
dc.description.sponsorshipLivCorp Inc.
dc.description.sponsorshipPet Trust Fund
dc.description.sponsorshipAtlantic Innovation Fund
dc.identifier.urihttp://hdl.handle.net/10214/8342
dc.language.isoenen_US
dc.publisherUniversity of Guelphen_US
dc.rights.licenseAll items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectCanine osteoarthritisen_US
dc.subjectmeloxicamen_US
dc.subjecttransdermal drug deliveryen_US
dc.subjectsynovialen_US
dc.titleEvaluation of a Transdermal Drug Delivery System for Veterinary Patientsen_US
dc.typeThesisen_US

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