A computational tool for investigating mechanistic relationships in the colon-diet-flora complex

dc.contributor.advisorEberl, Hermann J.
dc.contributor.authorMoorthy, Arun S.
dc.date.accessioned2015-09-03T20:18:33Z
dc.date.available2015-09-03T20:18:33Z
dc.date.copyright2015-07
dc.date.created2015-07-20
dc.date.issued2015-09-03
dc.degree.departmentDepartment of Mathematics and Statisticsen_US
dc.degree.grantorUniversity of Guelphen_US
dc.degree.nameDoctor of Philosophyen_US
dc.degree.programmeBiophysicsen_US
dc.description.abstractThe composition of the microflora inhabiting the colon and its affect on health has been a topic of international and cross-disciplinary interest for the better part of this century. With the advance of laboratory experiment and data acquisition techniques, there exists an excess of observation-based hypotheses circulating the gut literature. Many of these hypotheses have limited mechanistic evidence due to significant variability in methods and results. The general costs of experimentation make systematic and repeated investigation for improved reliability challenging. The compuGUT is a simulation tool developed to aid in the construction of mechanistic understanding underlying the interactions of intestinal microflora and their physical environment. It can be used to test existing hypotheses, evaluate contradictory claims, and suggest novel mechanisms. In this thesis I describe: (1) The construction of the underlying deterministic models, (2) the development and analysis of the compuGUT as a software tool, and (3) preliminary simulation investigations with potential biological implications, through the presentation of published and unpublished manuscripts and communications. The compuGUT is an important development in promoting a modeling-experimental iterative approach to studying intestinal microbiota. It will guide detailed investigation of the microbiota, its interactions, and its affects on health.en_US
dc.description.sponsorshipOntario Ministry of Agriculture, Food and Rural Affairs, Grant 200130
dc.identifier.urihttp://hdl.handle.net/10214/9140
dc.language.isoenen_US
dc.publisherUniversity of Guelphen_US
dc.rightsAttribution-ShareAlike 2.5 Canada*
dc.rights.urihttp://creativecommons.org/licenses/by-sa/2.5/ca/*
dc.subjectAnaerobic Digestionen_US
dc.subjectIntestinal Microbiotaen_US
dc.subjectMathematical Modelingen_US
dc.subjectNumerical Simulationen_US
dc.subjectSoftware Developmenten_US
dc.titleA computational tool for investigating mechanistic relationships in the colon-diet-flora complexen_US
dc.typeThesisen_US

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