Solid lipid nanoparticles stabilized with poloxamer 188 and tween 20; beta carotene stability and bioaccessibility

dc.contributor.advisorWright, A.J.
dc.contributor.authorLangmaid, Sarah
dc.date.accessioned2020-12-16T16:40:38Z
dc.date.available2020-12-16T16:40:38Z
dc.date.copyright2010
dc.degree.departmentDepartment of Human Health and Nutritional Sciencesen_US
dc.degree.grantorUniversity of Guelphen_US
dc.degree.nameMaster of Scienceen_US
dc.description.abstractCanola stearin solid lipid nanoparticles (SLN) and canola oil emulsions with 10 Poloxamer 188 (P188) or Tween 20 (T20) with and without 0.01 wt % [beta]-carotene (BC) were produced by high pressure homogenization. D4,3 in the range of 130 nm were obtained for both SLN and emulsion droplets. The influence of encapsulation on SLN properties, BC stability and bioaccessibility was determined. The presence of BC did not alter SLN size, polymorphism or melting behaviour over 90 days of storage at 4 or 20 °C. BC losses in the emulsions were higher than in the SLN (P<0.05) and with T20 compared to P188 (P<0.05). P188 SLN contained only the [beta] polymorph, while the T20 SLN contained both [beta]' and [beta] polymorphs up to Day 90. Bioaccessibility experiments using an 'in vitro' model of digestion revealed higher lipolysis for the emulsions versus SLN, but similar and low micellization of BC for all systems.en_US
dc.identifier.urihttps://hdl.handle.net/10214/23566
dc.language.isoen
dc.publisherUniversity of Guelphen_US
dc.rights.licenseAll items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectcanola stearinen_US
dc.subjectsolid lipid nanoparticlesen_US
dc.subjectcanola oilen_US
dc.subjectemulsionsen_US
dc.subject10 Poloxamer 188en_US
dc.subjectTween 20en_US
dc.subjectbeta-caroteneen_US
dc.subjectstabilityen_US
dc.subjectbioaccessibilityen_US
dc.titleSolid lipid nanoparticles stabilized with poloxamer 188 and tween 20; beta carotene stability and bioaccessibilityen_US
dc.typeThesisen_US

Files

Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Langmaid_Sarah_MSc.pdf
Size:
4.4 MB
Format:
Adobe Portable Document Format