Effects of 5alpha-androstane-3alpha,17beta-diol (3alpha diol) on Attention and Cortical Dendritic Morphology in the 3xTg Mouse Model of Alzheimer’s Disease

Simple item page
dc.contributor.advisorWinters, Boyer
dc.contributor.authorVisscher, Jacqueline
dc.date.accessioned2023-01-11T18:30:25Z
dc.date.available2023-01-11T18:30:25Z
dc.date.copyright2023
dc.date.created2022-12-16
dc.degree.departmentDepartment of Psychologyen_US
dc.degree.grantorUniversity of Guelphen
dc.degree.nameMaster of Scienceen_US
dc.degree.programmeNeuroscienceen_US
dc.description.abstractNeurosteroids promote neural cell survival, but their levels are significantly reduced in neurodegenerative diseases, including Alzheimer’s disease (AD). Recent work has suggested the androgen-derived, 5α-reduced metabolite 3α-diol may specifically contribute to this neuroprotection, as well as to sex differences in AD, although its mechanisms remain largely uncharacterized. Finasteride, a 5α-reductase inhibitor, has been associated with multiple long-lasting, adverse effects. As 5α-reduced metabolites may be critical in regulating neuroprotective effects of circulating steroids in the brain, the studies presented investigate the role of 3α-diol in AD pathology and importance of 5α-reduced metabolites in cognition and emotionality. We assessed long-term 3α-diol and finasteride treatment, respectively, observing alterations in task acquisition, decisional speed, impulsivity, and dendritic branching and length, as well as differential effects in the sexes. This research develops greater insight into the neurobiological basis of AD and aging, and advances the understanding of sex differences, with respect to 5α-reduced metabolites.en_US
dc.identifier.urihttps://hdl.handle.net/10214/27416
dc.language.isoenen_US
dc.publisherUniversity of Guelphen
dc.rights.licenseAll items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectAlzheimer'sen_US
dc.subject3xTg-ADen_US
dc.subjectAndrogensen_US
dc.subjectAttentionen_US
dc.subjectNeuroplasticityen_US
dc.subjectFinasterideen_US
dc.subjectNeuroprotectionen_US
dc.subjectNeurosteroid metabolitesen_US
dc.subjectGonadal steroid hormonesen_US
dc.subjectCortical morphologyen_US
dc.subject3alpha-diolen_US
dc.titleEffects of 5alpha-androstane-3alpha,17beta-diol (3alpha diol) on Attention and Cortical Dendritic Morphology in the 3xTg Mouse Model of Alzheimer’s Diseaseen_US
dc.typeThesisen
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Visscher_Jacqueline_202301_MSc.pdf
Size:
2.3 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Theses & Dissertations - All (2011-
Theses & Dissertations - Harvested by LAC