Pro-inflammatory interactions between neutrophils and platelets in the bovine

dc.contributor.advisorCoomber, Brenda L.
dc.contributor.advisorGentry, Patricia A.
dc.contributor.authorNoyes, Tina Michelle
dc.date.accessioned2020-12-04T15:04:00Z
dc.date.available2020-12-04T15:04:00Z
dc.date.copyright1999
dc.degree.departmentDepartment of Biomedical Sciencesen_US
dc.degree.grantorUniversity of Guelphen_US
dc.degree.nameMaster of Scienceen_US
dc.description.abstractPlatelets activated with the inflammatory mediator PAF were shown to release a soluble, heat stable mediator(s) capable of causing a respiratory burst and degranulation in neutrophils, in vitro, in a dose dependent manner. The amount of superoxide production, myeloperoxidase release, and alladine phosphatase release induced by activated platelet supernatant (APS) was not significantly different (p > 0.05) from that caused opsonized zymosan particles. Morphological changes typical of activated cells were induced in adherent neutrophils by APS. The APS was equally effective whether prepared from platelet rich plasma or gel-filtered platelets, indicating that the activation was due to a platelet-derived mediator and not plasma protein activity. Since bovine neutrophils were shown to be insensitive to the thromboxane A 2 analogue U46619, and as APS from acetylsalicylic acid pre-treated platelets was equally as active as normal APS, it was concluded that neutrophil activation was not due to thromboxane release by platelets.en_US
dc.identifier.urihttps://hdl.handle.net/10214/22436
dc.language.isoen
dc.publisherUniversity of Guelphen_US
dc.rights.licenseAll items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectbovineen_US
dc.subjectpro-inflammatory interactionsen_US
dc.subjectneurtohilsen_US
dc.subjectplateletsen_US
dc.subjectopsonized zymosan particlesen_US
dc.titlePro-inflammatory interactions between neutrophils and platelets in the bovineen_US
dc.typeThesisen_US

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