The Modulation of Obesity-associated Inflammatory Mediators and Skeletal Muscle Function by Dietary n-3 and n-6 Polyunsaturated Fatty Acids: A Time-course Study

dc.contributor.advisorRobinson, Lindsay
dc.contributor.authorWellings, Hannah
dc.date.accessioned2022-05-19T19:20:04Z
dc.date.available2022-05-19T19:20:04Z
dc.date.copyright2022-05
dc.date.created2022-05-13
dc.degree.departmentDepartment of Human Health and Nutritional Sciencesen_US
dc.degree.grantorUniversity of Guelphen
dc.degree.nameMaster of Scienceen_US
dc.degree.programmeHuman Health and Nutritional Sciencesen_US
dc.description.abstractDiets high in saturated fatty acids (SFA) contribute to obesity and lead to functional changes in adipose tissue (AT)-immune cell populations, altered production and secretion of inflammatory adipokines and, ultimately, dysregulated AT and skeletal muscle metabolism. Evidence suggests that a high fat diet containing either long-chain n-6 or n-3 polyunsaturated fatty acids (PUFA) can differentially modulate AT inflammatory adipokine secretion and improve insulin sensitivity in obese AT and skeletal muscle. Our findings suggest that dietary n-3 and n-6 PUFA alter AT inflammatory adipokines to different extents and in a time-dependent manner. Exposure of L6 myotubes to conditioned media generated from AT of rats fed different diets further modulated insulin signaling that was dependent on lipopolysaccharide stimulation and length of high fat diet consumption. Overall, this thesis suggests that dietary n-3 and n-6 PUFA can potentially improve AT and skeletal muscle metabolic function over time in an obese environment.en_US
dc.description.sponsorshipNatural Sciences and Engineering Research Council
dc.identifier.urihttps://hdl.handle.net/10214/26989
dc.language.isoenen_US
dc.publisherUniversity of Guelphen
dc.rights.licenseAll items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectobesityen_US
dc.subjectraten_US
dc.subjectinflammationen_US
dc.subjectpolyunsaturated fatty aciden_US
dc.subjectomega-3en_US
dc.titleThe Modulation of Obesity-associated Inflammatory Mediators and Skeletal Muscle Function by Dietary n-3 and n-6 Polyunsaturated Fatty Acids: A Time-course Studyen_US
dc.typeThesisen

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