Evaluation of interventions for Salmonella in chickens using research synthesis and quantitative exposure assessment
Systematic review-meta-analysis (SR-MA) was used to determine effectiveness estimates against 'Salmonella' concentration and frequency for different on-farm and processing treatments during broiler production. Results indicated that chilling may reduce 'Salmonella' concentration and frequency on broiler carcasses, but significant heterogeneity (p<0.1; I2>25%) precluded reporting pooled effectiveness estimates. These data were applied with those from other independently conducted SR-MAs and a scoping study (ScS) to generate inputs for a quantitative exposure assessment (QEA). The effectiveness of 2 individual farm and 6 processing interventions and a package of multiple interventions were compared within the Ontario context. A combination of farm and processing interventions pr04uced the largest reductions in 'Salmonella' concentration (99.87%) and prevalence (87.78%) relative to the baseline scenario. The ScS and SR-MAs provided a transparent and robust framework for selecting, evaluating and generating inputs for QEAs, however low methodological soundness and reporting of primary research prevented the full realization of their benefits.