Characterizing the Acute Cardiac, Pulmonary, and Diaphragmatic Remodelling Following Myocardial Infarction

dc.contributor.advisorSimpson, Jeremy A
dc.contributor.authorBirnbaum, Shara
dc.date.accessioned2018-07-26T13:08:02Z
dc.date.available2019-07-10T05:00:53Z
dc.date.copyright2018-07
dc.date.created2018-07-10
dc.date.issued2018-07-26
dc.degree.departmentDepartment of Human Health and Nutritional Sciencesen_US
dc.degree.grantorUniversity of Guelphen_US
dc.degree.nameMaster of Scienceen_US
dc.degree.programmeHuman Health and Nutritional Sciencesen_US
dc.description.abstractA myocardial infarction (MI) is the death of cardiomyocytes due to deprivation of blood flow to cardiac muscle. Although the respiratory system is a significant contributor to one-month mortality, there is a poor understanding of the acute changes following MI. The aim of this study was to address the early pathogenesis of the respiratory system by investigating the acute dysfunction of the lungs/ diaphragm post-MI. MIs were surgically induced in CD-1 male mice by permanent ligation of the left anterior descending coronary artery. Pulmonary dysfunction, characterized by edema, inflammation, and hemoglobin desaturation, was transient and peaked at 7 days post-MI. Diaphragm dysfunction, defined by reduced maximal in vivo strength, had a delayed onset but was persistent to study endpoint. A deeper understanding of the pathophysiological sequelae may direct future research into therapeutically targeting the respiratory system as a primary source of injury, changing the way that patients are treated post-MI.en_US
dc.identifier.urihttp://hdl.handle.net/10214/14056
dc.language.isoenen_US
dc.publisherUniversity of Guelphen_US
dc.rights.licenseAll items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectmyocardial infarctionen_US
dc.subjectrespiratoryen_US
dc.subjectcardiacen_US
dc.subjectpulmonaryen_US
dc.subjectlungsen_US
dc.subjecthearten_US
dc.titleCharacterizing the Acute Cardiac, Pulmonary, and Diaphragmatic Remodelling Following Myocardial Infarctionen_US
dc.typeThesisen_US

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