The effect of continuous treatment with 5α androstane-3α, 17-β diol (3α-diol) on protein markers in the triple transgenic mouse model of Alzheimer’s Disease

dc.contributor.advisorMacLusky, Neil
dc.contributor.authorBhullar, Simran
dc.date.accessioned2021-09-14T12:11:16Z
dc.date.available2021-09-14T12:11:16Z
dc.date.copyright2021-09
dc.date.created2021-09-07
dc.degree.departmentDepartment of Biomedical Sciencesen_US
dc.degree.grantorUniversity of Guelphen_US
dc.degree.nameMaster of Scienceen_US
dc.degree.programmeBiomedical Sciencesen_US
dc.description.abstractAge-related decrease in the levels of testosterone has been associated with an increased risk of developing Alzheimer’s Disease (AD). Supplementation with testosterone and dihydrotestosterone has been shown to improve AD-related neuropathology. Recently, their metabolite 5α-androstane-3α,17β-diol (3α-diol) has also shown to improve cognitive dysfunction in rodent models, and attenuate dysregulated extracellular signal-regulated kinase phosphorylation associated with β amyloid neurotoxicity in vitro. The role of continuous treatment with 3α-diol in an AD-animal model remains largely understudied. This thesis investigated the effect of continuous 3α-diol treatment on ERK and its phosphatase DUSP6, on protein markers associated with AD, and on astroglial and microglial markers in 6- and 9-month 3xTg-AD and wild-type male and female mice. No direct treatment effect of 3α-diol was seen, although multiple significant interactions were reported for certain markers. For the first time, the results present in the thesis provide evidence of the impact of 3α-diol supplementation on molecular markers associated with AD.en_US
dc.identifier.urihttps://hdl.handle.net/10214/26406
dc.language.isoenen_US
dc.publisherUniversity of Guelphen_US
dc.rights.licenseAll items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectAlzheimer's Diseaseen_US
dc.subjectsteroid hormonesen_US
dc.subject5α androstane-3α, 17-β diolen_US
dc.subject3α-diolen_US
dc.subjectneuroinflammationen_US
dc.subjecttestosterone metaboliteen_US
dc.titleThe effect of continuous treatment with 5α androstane-3α, 17-β diol (3α-diol) on protein markers in the triple transgenic mouse model of Alzheimer’s Diseaseen_US
dc.typeThesisen_US

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