Characterization and Identification of Circulating Stress Biomarkers Associated with the Holstein Stress and Tolerance Response to Bacterial Lipopolysaccharide

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dc.contributor.advisorKarrow, Niel
dc.contributor.advisorClow, Katie
dc.contributor.authorSullivan, Tianna
dc.date.accessioned2023-05-12T15:41:17Z
dc.date.available2023-05-12T15:41:17Z
dc.date.copyright2023-05-03
dc.date.created2023-05-03
dc.degree.departmentDepartment of Animal Biosciencesen_US
dc.degree.grantorUniversity of Guelphen
dc.degree.nameMaster of Scienceen_US
dc.degree.programmeAnimal Biosciencesen_US
dc.description.abstractGenetic selection of dairy cattle for improved stressed resiliency is one strategy for mitigating the harmful effects of stressors. With global temperatures increasing, there has been greater survival and distribution of pathogens within the environment. The hypothalamic-pituitary-adrenal (HPA) axis is responsible for regulating the host immune response, to ensure efficient pathogen clearance with minimal tissue damage, and for restoring homeostasis after stress event, which includes tissue repair. The purpose of this thesis was to develop an in-vivo bovine model of stress involving bacterial lipopolysaccharide (LPS) and to evaluate a comprehensive panel of stress biomarkers. Additionally, we sought to investigate the presence of an innate immune tolerance response in dairy heifers after repeated LPS challenges. Assessing the dynamic changes of stress biomarkers in response to an initial and repeated LPS challenge will help to characterize the kinetics of the stress response and identify biomarkers for genetic selection of stress resilient animals.en_US
dc.description.sponsorshipNatural Sciences and Engineering Research Council of Canada-CRD
dc.description.sponsorshipSemex Genetics
dc.description.sponsorshipMitacs
dc.description.sponsorshipFood from Thought
dc.description.sponsorshipCanada First Research Excellence Fund
dc.description.sponsorshipOntario Ministry of Agriculture, Food and Rural Affairs
dc.identifier.citationSullivan T, Sharma A, Lamers K, et al. Dynamic changes in Holstein heifer circulatory stress biomarkers in response to lipopolysaccharide immune challenge. Vet Immunol Immunopathol. 2022;248:110426. doi:10.1016/j.vetimm.2022.110426Sullivan
dc.identifier.citationT, Sharma A, Lamers K, Mallard BA, C?�novas A, Karrow NA. Immunotolerance of dairy heifers in response to repeated exposure to bacterial lipopolysaccharide endotoxin [published online ahead of print, 2023 Mar 16]. Vet Immunol Immunopathol. 2023;259:110579. doi:10.1016/j.vetimm.2023.110579
dc.identifier.urihttps://hdl.handle.net/10214/27562
dc.language.isoenen_US
dc.publisherUniversity of Guelphen
dc.rights.licenseAll items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectStressen_US
dc.subjectEndotoxinen_US
dc.subjectlipopolysaccharideen_US
dc.subjectHolsteinen_US
dc.subjecttoleranceen_US
dc.subjectBiomarkersen_US
dc.subjectmicroRNAen_US
dc.subjectCortisolen_US
dc.subjectCytokinesen_US
dc.titleCharacterization and Identification of Circulating Stress Biomarkers Associated with the Holstein Stress and Tolerance Response to Bacterial Lipopolysaccharideen_US
dc.typeThesisen
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