Sex and Developmental Differences in the Regulation of Neuron Excitability within Layer VI of the Mouse Entorhinal Cortex

dc.contributor.advisorBailey, Craig
dc.contributor.authorCollins, Cassandra
dc.date.accessioned2021-07-09T18:29:49Z
dc.date.available2021-07-09T18:29:49Z
dc.date.copyright2021-06
dc.date.created2021-06-23
dc.degree.departmentDepartment of Biomedical Sciencesen_US
dc.degree.grantorUniversity of Guelphen_US
dc.degree.nameMaster of Scienceen_US
dc.degree.programmeBiomedical Sciencesen_US
dc.description.abstractThe entorhinal cortex (EC) is important for learning and memory. Our laboratory recently identified a sex difference in the excitability of neurons within the sixth EC layer (ECVI) during early postnatal life, in that neurons from female mice are more excitable than neurons from male mice. While this sex difference correlates with a smaller afterhyperpolarization of medium duration (mAHP) in female ECVI neurons, its precise mechanisms have not been determined. Using whole-cell electrophysiology, this study aims to determine the contribution of small-conductance calcium-activated potassium (SK) channels toward ECVI neuron excitability in young postnatal (P5-10) and adult (P80-120) mice. Our findings demonstrate that SK channels do not regulate ECVI neuronal excitability in early postnatal life but do regulate excitability in adulthood. In adulthood, SK channels play a greater role in regulating ECVI neuron excitability in male mice than in female mice. This knowledge advances our understanding of neuron function within the hippocampal formation.en_US
dc.description.sponsorshipNatural Sciences and Engineering Research Council of Canada
dc.description.sponsorshipCanada Foundation for Innovation
dc.description.sponsorshipOntario Graduate Scholarship
dc.description.sponsorshipOntario Veterinary College Scholarship
dc.identifier.urihttps://hdl.handle.net/10214/25932
dc.language.isoenen_US
dc.publisherUniversity of Guelphen_US
dc.rights.licenseAll items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectHippocampal Formationen_US
dc.subjectPyramidal Neuronsen_US
dc.subjectNeuronen_US
dc.subjectElectrophysiologyen_US
dc.subjectWhole-Cell Electrophysiologyen_US
dc.subjectSex Differencesen_US
dc.subjectDevelopmenten_US
dc.subjectEntorhinal Cortexen_US
dc.subjectIon Channelsen_US
dc.subjectSK channelsen_US
dc.subjectExcitabilityen_US
dc.subjectAfterhyperpolarizationen_US
dc.titleSex and Developmental Differences in the Regulation of Neuron Excitability within Layer VI of the Mouse Entorhinal Cortexen_US
dc.typeThesisen_US

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