Natural killer cells in Yorkshire pigs selectively bred for high, control and low immune response

dc.contributor.advisorWilkie, Bruce N.
dc.contributor.authorRaymond, Claudine Rose-Marie of Pathobiologyen_US of Guelphen_US of Scienceen_US
dc.description.abstractPorcine NK cells are thought to regulate immune response. Thus, frequency and functional activity of NK cells were examined in generations six to eight (G6, G7, G8) of pigs, selectively bred for high, control, and low immune response. Peripheral blood lymphocytes expressing 5C6 ligand were phenotypically and functionally NK cells. Therefore, using 5C6 as a pan NK phenotype marker and target cell binding and lysis as assays of function, it was found that high and low response pigs had high and low NK cell frequencies respectively at G6 and G8. Functional assays differed by line with control pigs higher or similar to highs which were higher than lows. Vaccination with modified live transmissible gastroenteritis virus did not alter NK cell frequency within or between lines. Vaccination did change functional assay; lows ranked lowest while control and high were similar. Therefore, selection for immune response altered frequency and function of NK cells.en_US
dc.publisherUniversity of Guelphen_US
dc.rights.licenseAll items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectYorkshire pigsen_US
dc.subjectnatural killer cellsen_US
dc.subjecthigh immune responseen_US
dc.subjectcontrol immune responseen_US
dc.subjectlow immune responseen_US
dc.titleNatural killer cells in Yorkshire pigs selectively bred for high, control and low immune responseen_US


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