This thesis is an investigation of the challenges associated with fabrication methods of technology involving in-plane and out-of-plane optofluidic lenses. Current fabrication methods of in-plane optofluidic lenses are too expensive and complex to accommodate their increasing demand in modern technology, so simpler and cost-effective methods are required. Current endoscopic technology can be improved through the use of out-of-plane optofluidic lenses arranged on a curved surface in a 3-D compound-eye lens through providing the surgeon with a more accurate view of internal anatomy, resulting in decreased misdiagnosis rates. However, there are challenges associated with the fabrication methods of this curved surface. The purpose of this thesis is therefore to develop a fabrication method for in-plane optofluidic lenses using simple and cost-effective procedures involving the material graphene and to overcome the challenges associated with fabricating the surface required for the 3-D compound-eye lens.