A Novel Method of Sub-milimeter Range Verification for Hadron Therapy using a Tumour Marker
In this work, we present a novel technique for in-vivo proton therapy range verification, and share the results of multiple experiments to determine its feasibility. This technique makes use of a hadron tumour marker (HTM), implanted at a short distance from the clinical treatment volume. Signals emitted from the marker during treatment can provide a direct measurement of the proton beam energy at the marker's position.
The method was initially investigated through a Monte Carlo simulation, followed by two experiments at TRIUMF, in which candidate markers were activated with a variety of proton energies. Finally, the method was extended to heavy-ion therapy in an experiment using a
C. Burbadge, E. Kasanda, V. Bildstein, G. Dublin, B. Olaizola, C. Hoehr, and D. Muecher, Phys. Med. Biol. 66, 025005 (2021). https://doi.org/10.1088/1361-6560/abbd15.