The pharmacological inhibition of the neuropeptide Y1 and Y5 receptors on proliferation, migration, and cell signaling in hypoxic breast carcinomas

dc.contributor.advisorUniacke, Jim
dc.contributor.authorKirsh, Sarah
dc.date.accessioned2022-08-10T17:47:00Z
dc.date.copyright2022-08
dc.date.created2022-07-12
dc.degree.departmentDepartment of Molecular and Cellular Biologyen_US
dc.degree.grantorUniversity of Guelphen
dc.degree.nameMaster of Scienceen_US
dc.degree.programmeMolecular and Cellular Biologyen_US
dc.description.abstractNeuropeptide Y (NPY) has been linked to the initiation and progression of breast cancer. NPY activates six G-protein coupled receptors (GPCRs) in breast cancer, of which, NPY1R and NPY5R are the most biologically significant. Activation of these receptors by peptide binding impacts tumour proliferation, migration, invasion, and angiogenesis, especially in hypoxia. Here we show that the use of NPY1R and NPY5R antagonists in MDA-MB-231 and MCF7 breast cancer lines can inhibit hallmarks of cancer and that NPYRs are associated with hypoxic regions in tumour samples. These overlaps correlated with adverse outcomes. Breast cancer is the second most common cancer, with more than 1.3 million people diagnosed each year. Therefore, a greater understanding of how NPY1R and NPY5R antagonists impact breast cancer cell migration, proliferation, invasion, and formation, with a focus on hypoxia, will be an asset in the development of novel therapeutics for breast carcinomas.en_US
dc.description.embargo2023-07-11
dc.description.sponsorshipOntario Graduate Scholarship
dc.description.sponsorshipCancer Research Society
dc.identifier.citationMedeiros, P.J., Pascetta, S.A., Kirsh, S.M., Al-Khazraji, B.K., and Uniacke, J. (2022). Expression of hypoxia inducible factor-dependent neuropeptide Y receptors Y1 and Y5 sensitizes hypoxic cells to NPY stimulation. J. Biol. Chem. 298, 101645. https://doi.org/10.1016/j.jbc.2022.101645
dc.identifier.urihttps://hdl.handle.net/10214/27079
dc.language.isoenen_US
dc.publisherUniversity of Guelphen
dc.rights.licenseAll items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectHypoxiaen_US
dc.subjectNPYen_US
dc.subjectBreast canceren_US
dc.subjectGPCRen_US
dc.titleThe pharmacological inhibition of the neuropeptide Y1 and Y5 receptors on proliferation, migration, and cell signaling in hypoxic breast carcinomasen_US
dc.typeThesisen

Files

Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Kirsh_Sarah_202208_MSc.pdf
Size:
91.19 MB
Format:
Adobe Portable Document Format
Description: