Feeding butter with elevated content of trans-10, cis-12 conjugated linoleic acid to obese-prone rats impairs glucose and insulin tolerance

dc.contributor.advisorHamilton, Melissa
dc.contributor.advisorDyck, David
dc.contributor.authorHamilton, Melissa
dc.date.accessioned2015-09-04T14:47:39Z
dc.date.available2015-09-04T14:47:39Z
dc.date.copyright2015-08
dc.date.created2015-08-26
dc.date.issued2015-09-04
dc.degree.departmentDepartment of Human Health and Nutritional Sciencesen_US
dc.degree.grantorUniversity of Guelphen_US
dc.degree.nameMaster of Scienceen_US
dc.degree.programmeHuman Health and Nutritional Sciencesen_US
dc.descriptionOne of the first studies to examine the effects from consuming a naturally enriched source of CLA t10,c12en_US
dc.description.abstractThis study was conducted to evaluate dietary CLAt10c12 consumption by obese prone rats considering supplemental doses have shown to contribute to the development of insulin resistance. We created butter from cows with subacute ruminal acidosis (SARA), a condition that decreases the pH of a dairy cow’s rumen and increases CLAt10c12 10-fold making this an enriched naturally occurring source of CLAt10c12. We evaluated if SARA butter would result in a greater risk of developing glucose and insulin intolerance, impaired insulin signaling and increased markers of inflammation compared to various diets (Lean Zuckers: low (10%) fat (LF), Obese Zuckers: LF, 45% lard, 45% non-SARA butter). After 8 weeks, SARA was comparable with Lard for its negative impact on glucose and insulin tolerance, followed by non- SARA, LF and leans respectively. Differences were not reflected in the insulin signaling markers. Markers of inflammation were variable across tissues (adipose, skeletal muscle, liver).en_US
dc.description.sponsorshipDairy Farmers of Ontario
dc.description.sponsorshipOntario Ministry of Agriculture, Food and Rural Affairs
dc.identifier.urihttp://hdl.handle.net/10214/9148
dc.language.isoenen_US
dc.publisherUniversity of Guelphen_US
dc.rights.licenseAll items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectCLAen_US
dc.subjectConjugated Linoleic Aciden_US
dc.subjectInsulin Resistanceen_US
dc.subjectGlucose Intoleranceen_US
dc.subjectInsulin Intoleranceen_US
dc.subjectButteren_US
dc.subjectSubacute Ruminal Acidosisen_US
dc.subjectNaturalen_US
dc.subjectObesityen_US
dc.subjectZuckeren_US
dc.subjectRatsen_US
dc.titleFeeding butter with elevated content of trans-10, cis-12 conjugated linoleic acid to obese-prone rats impairs glucose and insulin toleranceen_US
dc.typeThesisen_US

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