Prior exercise training improves cold tolerance independent of indices associated with non-shivering thermogenesis

dc.contributor.advisorWright, David C
dc.contributor.authorKnuth, Carly Michelle
dc.date.accessioned2018-07-25T14:43:30Z
dc.date.available2018-07-25T14:43:30Z
dc.date.copyright2018-07
dc.date.created2018-07-06
dc.date.issued2018-07-25
dc.degree.departmentDepartment of Human Health and Nutritional Sciencesen_US
dc.degree.grantorUniversity of Guelphen_US
dc.degree.nameMaster of Scienceen_US
dc.degree.programmeHuman Health and Nutritional Sciencesen_US
dc.description.abstractThe purpose of this thesis was to determine whether previous exercise training via voluntary wheel running (VWR) would improve cold tolerance by protecting against cold-induced reductions in rectal temperature. We hypothesized that this would be associated with an exercise-induced increase in white adipose tissue browning, which would contribute in an additive manner to cold-induced nonshivering thermogenesis. To examine this, male C57BL6 mice remained sedentary or were given free access to a wheel for 12 days. Mice were then kept at room temperature (25oC) or subjected to cold stress (4oC) for a period of 48 hours. The primary findings were two-fold; 1) prior exercise via VWR protects against cold-induced weight loss, through a mechanism involving increases in food intake and 2) prior exercise via VWR protects against cold-induced reductions in rectal temperature, however this is likely not associated with UCP-1-dependent nonshivering thermogenesis. Rather, the capacity for shivering thermogenesis may be enhanced.en_US
dc.identifier.urihttp://hdl.handle.net/10214/14053
dc.language.isoenen_US
dc.publisherUniversity of Guelphen_US
dc.rightsAttribution-NoDerivs 2.5 Canada*
dc.rights.urihttp://creativecommons.org/licenses/by-nd/2.5/ca/*
dc.subjectexerciseen_US
dc.subjectcolden_US
dc.subjectadiposeen_US
dc.subjectthermogenesisen_US
dc.subjectUCPen_US
dc.subjectmiceen_US
dc.subjectbrowningen_US
dc.subjectglucoseen_US
dc.titlePrior exercise training improves cold tolerance independent of indices associated with non-shivering thermogenesisen_US
dc.typeThesisen_US

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