The Role of Membrane-Bound Receptors in the Rapid Estrogenic Enhancements of Learning and Memory Within the Hippocampus

dc.contributor.advisorCholeris, Elena
dc.contributor.authorKuun, Talya
dc.date.accessioned2021-01-19T20:35:25Z
dc.date.available2021-01-19T20:35:25Z
dc.date.copyright2021-01
dc.date.created2021-01-07
dc.degree.departmentDepartment of Psychologyen_US
dc.degree.grantorUniversity of Guelphen_US
dc.degree.nameMaster of Scienceen_US
dc.degree.programmeNeuroscienceen_US
dc.description.abstractEstrogens play a role in learning and memory on a rapid time scale. Systemic treatment with 17β-estradiol rapidly improves object recognition, social recognition and object place learning in ovariectomized female mice within a timescale of only 40 minutes following administration. Studies have identified the dorsal hippocampus as one site of these estrogenic enhancing effects. Whether these rapid estrogenic effects are mediated solely by membrane-bound estrogen receptors is currently unknown. This study sought to determine the role of membrane estrogen receptors in the rapid effects of 17-β estradiol within the hippocampus. By conjugating 17-β estradiol to a large bovine serum albumin molecule (BSA-E2), the estradiol is prevented from passing through the cellular membrane and thus, from binding to intracellular receptors. We were able to demonstrate that the rapid effects of estrogens on learning and memory are mediated by membrane-bound estrogen receptors, independent of intracellular mechanisms.en_US
dc.identifier.urihttps://hdl.handle.net/10214/23767
dc.language.isoenen_US
dc.publisherUniversity of Guelphen_US
dc.rights.licenseAll items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectHippocampusen_US
dc.subjectDorsal Hippocampusen_US
dc.subjectBSA-E2en_US
dc.subjectMembrane-Bound Estrogen Receptorsen_US
dc.subjectEstrogensen_US
dc.subjectEstradiolen_US
dc.subjectSocial Recognitionen_US
dc.subjectObject Recognitionen_US
dc.subjectObject Placementen_US
dc.subjectLearningen_US
dc.subjectMemoryen_US
dc.subjectRapiden_US
dc.titleThe Role of Membrane-Bound Receptors in the Rapid Estrogenic Enhancements of Learning and Memory Within the Hippocampusen_US
dc.typeThesisen_US

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