Supplementation of omega-3 fatty acids as a strategy to regulate postpartum inflammation in dairy cows

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dc.contributor.advisorRibeiro, Eduardo
dc.contributor.authorVan Winters, Bryn
dc.date.accessioned2023-01-12T21:21:39Z
dc.date.available2023-01-12T21:21:39Z
dc.date.copyright2023-01
dc.date.created2023-01-11
dc.degree.departmentDepartment of Animal Biosciencesen_US
dc.degree.grantorUniversity of Guelphen
dc.degree.nameMaster of Scienceen_US
dc.degree.programmeAnimal Biosciencesen_US
dc.description.abstractThe objectives of this thesis were to 1) evaluate the impact of supplementing omega-3 (n3) fatty acids (FA) using calcium salts enriched in fish oil (Ca-FO) in the early postpartum period on the degree and resolution of inflammation using an induced acute inflammation model, and 2) test whether these effects were from the increased energy density of the diet or the impacts of n3 FA on immune cell biology. Supplementing Ca-FO resulted in changes to the composition of plasma, milk, and peripheral blood leukocytes. Increased basal and endotoxin-induced concentrations of IFNγ and MIP1ɑ, attenuated febrile responses to the endotoxin challenge, and greater rumen activity one day after endotoxin-induced inflammation suggest that supplementation with n3 FA can alter postpartum inflammation.en_US
dc.description.sponsorshipOntario Agri-Food Innovation Alliance
dc.description.sponsorshipVirtus Nutrition
dc.identifier.urihttps://hdl.handle.net/10214/27441
dc.language.isoenen_US
dc.publisherUniversity of Guelphen
dc.rights.licenseAll items in the Atrium are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectInflammationen_US
dc.subjectDairy cowen_US
dc.subjectOmega-3 Fatty Acidsen_US
dc.subjectPostpartumen_US
dc.subjectFish oilen_US
dc.titleSupplementation of omega-3 fatty acids as a strategy to regulate postpartum inflammation in dairy cowsen_US
dc.typeThesisen
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