Various species of teleost fish and salamanders can spontaneously generate new neurons following an injury to the central nervous system (CNS) – a process known as reactive neurogenesis. Here, I investigated the role of reactive neurogenesis in restoring function after a CNS injury in the leopard gecko (Eublepharis macularius). To induce a telencephalon lesion, I administered a single dose of the neurotoxin 3-acetylpyridine (3-AP). Twenty days after 3-AP administration, I observed a significant decline in the number of total neurons in the telencephalon and deficits in spatial memory. However, by 60 days post-injury (dpi), the number of neurons within the telencephalon had significantly increased compared to the 20-dpi cohort, coinciding with functional improvements in spatial memory learning. Together, these data provide the first evidence that the leopard gecko can achieve functional regeneration after a telencephalon injury.