The objective of this review is to evaluate the comparative efficacy of antibiotics or antibiotic treatment regimes for the treatment of clinical mastitis in milking dairy cows, using bacteriological and clinical cures as the primary outcomes. This aim will be met through two stages: 1.) Conduct a systematic review and meta-analyses to identify and summarize the results of all clinical trials conducted to evaluate the efficacy of antibiotics for the treatment of clinical mastitis in dairy cattle, and 2.) Conduct a network meta-analysis to evaluate the comparative efficacy of different antibiotic treatments or regimes for both bacteriologic and clinical cure.