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Salmonella antibody response on commercial swine farms and its association with host genetics and isolation of Salmonella on-farm and at slaughter

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dc.contributor.advisor Lillie, Brandon
dc.contributor.advisor Farzan, Vahab
dc.contributor.author Schut, Corinne
dc.date.accessioned 2019-01-11T20:45:20Z
dc.date.available 2019-01-11T20:45:20Z
dc.date.copyright 2019-01
dc.date.created 2019-01-04
dc.date.issued 2019-01-11
dc.identifier.uri http://hdl.handle.net/10214/14776
dc.description.abstract Salmonella in pork is a concern. This study characterized pig antibody responses on-farm and their association with Salmonella shedding/tissue colonization and host genetic variants. Fourteen cohorts of pigs from eight farms (total = 809) were tested five times (weaning to slaughter). Blood and feces/tissues were analyzed via ELISA and culturing. Data were analyzed using mixed-effects logistic regression models. Overall, 20.7% of sera tested positive for Salmonella antibodies and 12.6% of fecal samples tested positive for Salmonella. Older pigs and pigs shedding Salmonella were more likely to test seropositive (p < 0.05). There was no association between seropositivity and Salmonella at slaughter. Variants in/near PTPRJ (p = 0.0000066), ST6GALNAC3 (p = 0.0000099), and DCDC2C (p < 0.0000086) were associated with Salmonella susceptibility, while variants in AKAP12 (p < 0.0000358) and RALGAPA2 (p = 0.0000760) may be associated. This work may aid research in reducing Salmonella on-farm, benefiting researchers and the public. en_US
dc.description.sponsorship NSERC, OMAFRA, Swine Innovation Porc, the Canadian Center for Swine Improvement, Alliance Genetics Canada, and Ontario Pork. en_US
dc.language.iso en en_US
dc.subject Salmonella en_US
dc.subject Antibody response en_US
dc.subject Shedding en_US
dc.subject Genetics en_US
dc.subject Prevalence en_US
dc.subject GWAS en_US
dc.subject Genome-wide association study en_US
dc.title Salmonella antibody response on commercial swine farms and its association with host genetics and isolation of Salmonella on-farm and at slaughter en_US
dc.type Thesis en_US
dc.degree.programme Pathobiology en_US
dc.degree.name Master of Science en_US
dc.degree.department Department of Pathobiology en_US


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