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Dietary fat consumption and exercise as strategies to mitigate tumorigenesis in breast cancer

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Title: Dietary fat consumption and exercise as strategies to mitigate tumorigenesis in breast cancer
Author: Hucik, Barbora
Department: Department of Human Health and Nutritional Sciences
Program: Human Health and Nutritional Sciences
Advisor: Robinson, Lindsay EMa, David WL
Abstract: Lifestyle habits such as regular exercise or the consumption of a healthy balanced diet may prevent up to 30-50% of breast cancer (BC) cases. Dietary fats are of specific interest, as research provides strong evidence regarding the association of different dietary fats and BC. Exercise also exerts protective effects in BC, yet the combination of various dietary fats and exercise has not been well-studied. Dietary fats exert anti-tumorigenic effects in BC via the incorporation of fatty acids into tumor tissue plasma membrane. This study shows that dietary fat and exercise independently modulate mammary tumor outcomes. Tumor volume and multiplicity was decreased in mice fed n-3 PUFA. Exercise inhibited tumor onset and development in n-6 PUFA-fed mice. Diet and exercise interventions should be investigated further as a means to improve mammary tumor outcomes in BC.
URI: http://hdl.handle.net/10214/11582
Date: 2017-09-13


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